4.7 Review

Targeting angiopoietin-like 3 in atherosclerosis: From bench to bedside

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Triglyceride-rich lipoproteins, apolipoprotein C-III, angiopoietin-like protein 3, and cardiovascular events in older adults: Atherosclerosis Risk in Communities (ARIC) study

Aliza Hussain et al.

Summary: Despite statin and antihypertensive therapies, older Americans continue to have high ASCVD risk. Novel measures of triglyceride-rich lipoproteins are associated with ASCVD, and genetic polymorphisms related to triglyceride catabolism are potential therapeutic targets. In older adults, LDL-TG and ANGPTL3 are independent predictors of ASCVD events after adjustment for traditional risk factors.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

Review Endocrinology & Metabolism

Lipoprotein Lipase and Its Regulators: An Unfolding Story

Shuangcheng Alivia Wu et al.

Summary: Lipoprotein lipase (LPL) plays a crucial role in systemic lipid partitioning and metabolism. Recent studies on LPL crystal structure and the discovery of new regulators have significantly improved our understanding of its biology.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Review Endocrinology & Metabolism

Novel therapies for familial hypercholesterolemia

Farzahna Mohamed et al.

Summary: Familial hypercholesterolemia is a genetic disorder characterized by high LDL cholesterol levels and increased risk of cardiovascular disease. Traditional lipid-lowering therapies are often insufficient, but novel treatments such as PCSK9 inhibitors, Inclisiran, and Evinacumab have shown significant reductions in LDL-C levels, providing effective options for patients with this condition.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2021)

Article Biochemistry & Molecular Biology

The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage

Najia Jin et al.

Summary: The study shows that angiopoietin-like proteins 3 and 8 (ANGPTL3/8) can inhibit the enzymatic activities of lipoprotein lipase (LPL) by promoting furin-mediated cleavage of LPL. This effect is stronger than using ANGPTL3 or ANGPTL8 alone.

ACS CHEMICAL BIOLOGY (2021)

Article Hematology

ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia-Brief Report

Laurens F. Reeskamp et al.

Summary: The study found that treatment with evinacumab is associated with an increase in the fractional catabolic rate of apoB-containing lipoproteins, suggesting that it lowers LDL-cholesterol mainly through increased clearance of these lipoproteins.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Review Endocrinology & Metabolism

Advances in biological therapies for dyslipidemias and atherosclerosis

Eftaxia-Konstantina Valanti et al.

Summary: Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle, and environmental factors. Targeting genes involved in lipoprotein metabolism is considered a new approach for prevention and treatment. Multiple lipid lowering biological therapies have been approved by the FDA with impressive results in clinical trials.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

News Item Biotechnology & Applied Microbiology

FDA approves first anti-ANGPTL3 antibody, for rare cardiovascular indication

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Min Qiu et al.

Summary: Loss-of-function mutations in Angiopoietin-like 3 (Angptl3) are linked to reduced blood lipid levels, making it a potential therapeutic target for lipid metabolism disorders. A lipid nanoparticle delivery system successfully edited Angptl3 gene in vivo, leading to significant reductions in lipid levels without off-target effects or toxicity, highlighting the potential of this platform for safe and effective gene editing therapies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cardiac & Cardiovascular Systems

New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B

Nick S. Nurmohamed et al.

Summary: Novel therapies targeting LDL-C, including inclisiran, bempedoic acid, ANGPTL3 inhibitors, and CETP inhibitors, provide important tools for the prevention of cardiovascular disease.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Global epidemiology of dyslipidaemias

Angela Pirillo et al.

Summary: Dyslipidaemias are alterations to the plasma lipid profile associated with clinical conditions, with high cholesterol being the most common form and a major risk factor for cardiovascular disease. Treating lipid abnormalities may reduce the risk of cardiovascular disease in patients with diabetes.

NATURE REVIEWS CARDIOLOGY (2021)

Article Multidisciplinary Sciences

ANGPTL3 gene variants in subjects with familial combined hyperlipidemia

A. M. Bea et al.

Summary: The study found no gain-of-function (GOF) mutations in the ANGPTL3 gene in subjects with familial combined hyperlipidemia (FCHL), but identified four variants in FCHL patients, with one variant showing a significantly different frequency compared to normolipemic controls.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition

Yan Q. Chen et al.

Summary: ApoA5 likely decreases TG by suppressing ANGPTL3/8-mediated LPL inhibition, without having a direct effect on LPL. These findings reveal a novel intersection of ApoA5 and ANGPTL3/8 in the regulation of TG metabolism.

JOURNAL OF LIPID RESEARCH (2021)

Editorial Material Cardiac & Cardiovascular Systems

Triglyceride lowering 2.0: back to the future?

Chris J. Packard

EUROPEAN HEART JOURNAL (2020)

Article Cardiac & Cardiovascular Systems

Remnant cholesterol, coronary atheroma progression and clinical events in statin-treated patients with coronary artery disease

Mohamed B. Elshazly et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice[S]

Marianne G. Pouwer et al.

JOURNAL OF LIPID RESEARCH (2020)

Editorial Material Biochemistry & Molecular Biology

ANGPTL3, PCSK9, and statin therapy drive remarkable reductions in hyperlipidemia and atherosclerosis in a mouse model

Eva Hurt-Camejo

JOURNAL OF LIPID RESEARCH (2020)

Article Biochemistry & Molecular Biology

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi[S]

Andrew A. Butler et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

Long-Term Evolocumab in Patients With Familial Hypercholesterolemia

Raul D. Santos et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Editorial Material Endocrinology & Metabolism

Familial Hypercholesterolemia and Atherosclerosis: Animal Models and Therapeutic Advances

Suowen Xu et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

Article Cardiac & Cardiovascular Systems

High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

Ming-Chun Chen et al.

INTERNATIONAL JOURNAL OF HYPERTENSION (2020)

Review Pharmacology & Pharmacy

Lipid lowering therapy in cardiovascular disease: From myth to molecular reality

Philipp Mourikis et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Rene C. Adam et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Biochemistry & Molecular Biology

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids

Yan Q. Chen et al.

JOURNAL OF LIPID RESEARCH (2020)

Letter Cardiac & Cardiovascular Systems

LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase

Liya Wu et al.

CIRCULATION RESEARCH (2020)

Article Medicine, General & Internal

Evinacumab for Homozygous Familial Hypercholesterolemia

Frederick J. Raal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Evinacumab in Patients with Refractory Hypercholesterolemia

Robert S. Rosenson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation

Mohamed Abu-Farha et al.

PROGRESS IN LIPID RESEARCH (2020)

Article Hematology

Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State

Emmi Tikkanen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Review Pharmacology & Pharmacy

Harnessing nucleic acid-based therapeutics for atherosclerotic cardiovascular disease: state of the art

Fatemeh Vandat Lasemi et al.

DRUG DISCOVERY TODAY (2019)

Review Cell Biology

The next generation of CRISPR-Cas technologies and applications

Adrian Pickar-Oliver et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism

Longyan Yang et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Medicine, General & Internal

Atherosclerosis

Peter Libby et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Review Medicine, General & Internal

Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease

Erin D. Michos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, Research & Experimental

Antibodies to watch in 2019

Helene Kaplon et al.

Review Cardiac & Cardiovascular Systems

Angiopoietin-Like 3 From Discovery to Therapeutic Gene Editing

Xiao Wang et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2019)

Article Cardiac & Cardiovascular Systems

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol

Yu-Xin Xu et al.

ATHEROSCLEROSIS (2018)

Letter Cardiac & Cardiovascular Systems

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

Alexandra C. Chadwick et al.

CIRCULATION (2018)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2018 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2018)

Article Biochemistry & Molecular Biology

DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

Wei-Jun Li et al.

LIPIDS IN HEALTH AND DISEASE (2018)

Review Biochemistry & Molecular Biology

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases

Xin Su et al.

LIPIDS IN HEALTH AND DISEASE (2018)

Editorial Material Cardiac & Cardiovascular Systems

In vivo genome editing of ANGPTL3: a therapy for atherosclerosis?

June-Wha Rhee et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Multidisciplinary Sciences

CRISPR-Cas guides the future of genetic engineering

Gavin J. Knott et al.

SCIENCE (2018)

Article Medicine, General & Internal

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

G. G. Schwartz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Cardiac & Cardiovascular Systems

Angiopoietin-Like 3 (ANGPTL3) and Atherosclerosis: Lipid and Non-Lipid Related Effects

Maria Giovanna Lupo et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2018)

Review Cardiac & Cardiovascular Systems

PCSK9 Inhibitors Economics and Policy

Mark A. Hlatky et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

Nathan O. Stitziel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Genetics: ANGPTL3 deficiency protects from CAD

Irene Fernández-Ruiz

Nature Reviews Cardiology (2017)

Review Endocrinology & Metabolism

Angiopoietin-like 3 in lipoprotein metabolism

Sander Kersten

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Medicine, General & Internal

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Marc S. Sabatine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Letter Medicine, General & Internal

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

Daniel Gaudet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

Mark J. Graham et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

F. E. Dewey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Molecular Mechanisms of Antisense Oligonucleotides

Stanley T. Crooke

NUCLEIC ACID THERAPEUTICS (2017)

Article Cardiac & Cardiovascular Systems

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3

Federico Oldoni et al.

ATHEROSCLEROSIS (2016)

Article Endocrinology & Metabolism

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

P. A. Nidhina Haridas et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Biochemistry & Molecular Biology

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

Yan Wang et al.

JOURNAL OF LIPID RESEARCH (2015)

Article Biochemistry & Molecular Biology

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

Viktoria Gusarova et al.

JOURNAL OF LIPID RESEARCH (2015)

Article Hematology

Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits

Nidhi Mehta et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction

Anders Berg Jorgensen et al.

EUROPEAN HEART JOURNAL (2013)

Article Gastroenterology & Hepatology

MicroRNA-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia

Kasey C. Vickers et al.

HEPATOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Serum Lipids and Lipoproteins in Chinese Men and Women

Wenying Yang et al.

CIRCULATION (2012)

Article Cardiac & Cardiovascular Systems

Characterization of Three Kindreds With Familial Combined Hypolipidemia Caused by Loss-of-Function Mutations of ANGPTL3

Livia Pisciotta et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2012)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Angiopoietin-like Protein 3 Inhibits Lipoprotein Lipase Activity through Enhancing Its Cleavage by Proprotein Convertases

Jun Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

Marius R. Robciuc et al.

JOURNAL OF LIPID RESEARCH (2010)

Article Multidisciplinary Sciences

Biological, clinical and population relevance of 95 loci for blood lipids

Tanya M. Teslovich et al.

NATURE (2010)

Article Medicine, General & Internal

Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia

Kiran Musunuru et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemical Research Methods

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

Rui Chen et al.

JOURNAL OF PROTEOME RESEARCH (2009)

Article Genetics & Heredity

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Cristen J. Willer et al.

NATURE GENETICS (2008)

Article Cell Biology

Hepatic proprotein convertases modulate HDL metabolism

Weijun Jin et al.

CELL METABOLISM (2007)

Article Hematology

Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase

Mitsuru Shimamura et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone

C Fugier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells

CC Zhang et al.

NATURE MEDICINE (2006)

Article Biochemistry & Molecular Biology

Differential regulation and properties of angiopoietin-like proteins 3 and 4

HF Ge et al.

JOURNAL OF LIPID RESEARCH (2005)

Article Biochemistry & Molecular Biology

Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor

M Shimamura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states

K Inukai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

Y Ando et al.

JOURNAL OF LIPID RESEARCH (2003)

Article Biochemistry & Molecular Biology

ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase

T Shimizugawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin αvβ3 and induces blood vessel formation in vivo

G Camenisch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Genetics & Heredity

Angptl3 regulates lipid metabolism in mice

R Koishi et al.

NATURE GENETICS (2002)

Article Biochemistry & Molecular Biology

Regulation of lipoprotein lipase by the oxysterol receptors, LXRα and LXRβ

Y Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Multidisciplinary Sciences

Atherosclerosis

AJ Lusis

NATURE (2000)