期刊
DIABETES CARE
卷 44, 期 8, 页码 1757-1765出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc21-0236
关键词
-
资金
- Netherlands Organization for Scientific Research [NWO Veni 016.186.012]
- Dutch Diabetes Research Foundation [2017-81-014]
- NIGRAM21 consortium [LSHM17034]
- Dutch Kidney Foundation [16TKI02]
- ZonMW NWO-Vidi [91 71 8304]
- PPP Allowance [LSHM17034]
The study found that serum magnesium (Mg2+) concentration is inversely associated with the development of heart failure (HF) and atrial fibrillation (AF) as well as the occurrence of chronic kidney disease (CKD), diabetic retinopathy, and diabetic foot complications in type 2 diabetes patients. Additionally, glycemic control, as measured by hemoglobin A(1c) [HbA(1c)], partially mediated the association between serum Mg2+ and HF and microvascular complications.
OBJECTIVE We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (hemoglobin A(1c) [HbA(1c)]), in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We analyzed in 4,348 participants the association of serum Mg2+ with macrovascular disease and mortality (acute myocardial infarction [AMI], coronary heart disease [CHD], heart failure [HF], cerebrovascular accident [CVA], and peripheral arterial disease [PAD]), atrial fibrillation (AF), and microvascular complications (chronic kidney disease [CKD], diabetic retinopathy, and diabetic foot) using Cox regression, adjusted for confounders. Mediation analysis was performed to assess whether HbA(1c) mediated these associations. RESULTS The average baseline serum Mg2+ concentration was 0.80 +/- 0.08 mmol/L. During 6.1 years of follow-up, serum Mg2+ was inversely associated with major macrovascular, 0.87 (95% CI 0.76; 1.00); HF, 0.76 (95% CI 0.62; 0.93); and AF, 0.59 (95% CI 0.49; 0.72). Serum Mg2+ was not associated with AMI, CHD, CVA, and PAD. During 5.1 years of follow-up, serum Mg2+ was inversely associated with overall microvascular events, 0.85 (95% CI 0.78; 0.91); 0.89 (95% CI 0.82; 0.96) for CKD, 0.77 (95% CI 0.61; 0.98) for diabetic retinopathy, and 0.85 (95% CI 0.78; 0.92) for diabetic foot. HbA(1c) mediated the associations of serum Mg2+ with HF, overall microvascular events, diabetic retinopathy, and diabetic foot. CONCLUSIONS Serum Mg2+ concentration is inversely associated with the risk to develop HF and AF and with the occurrence of CKD, diabetic retinopathy, and foot complications in T2D. Glycemic control partially mediated the association of serum Mg2+ with HF and microvascular complications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据