期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 63, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/dev.22153
关键词
amygdala; hippocampus; income; material hardship; sensitive period
It is well known that financial disadvantage can impact brain development in critical regions like the hippocampus and the amygdala. Lower family income at early developmental stages is associated with smaller volumes of these structures, with the mediating factor being unmet basic needs.
It is well known that financial disadvantage is associated with alterations in brain development in regions critical to socioemotional well-being such as the hippocampus and the amygdala. Yet little is known about whether family income at different points in development is differentially associated with these structures. Furthermore, little is known about which environmental factors statistically mediate associations between income and subcortical structure. Using a longitudinal birth cohort and linear mixed-effects models, we identified associations between income-to-needs ratio (INR) at 6 timepoints throughout childhood and hippocampal and amygdala volumes at age 7-9 years (n = 41; 236 INR measurements; 41 brain measurements). Mediation analysis identified environmental sequelae of income that statistically accounted for INR-brain associations. Lower INR prior to age 4 was associated with smaller hippocampal volumes, whereas lower INR prior to age 2 was associated with smaller right amygdala volume. These associations were mediated by unmet basic needs (e.g., food, housing). These findings delineate the temporal specificity of associations between income and hippocampal and amygdala structures.
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