4.4 Review

Emerging roles of MT-MMPs in embryonic development

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Review Biochemistry & Molecular Biology

Multifunctional intracellular matrix metalloproteinases: implications in disease

Wesam Bassiouni et al.

Summary: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that were initially discovered as proteases targeting extracellular proteins. However, recent research has revealed their crucial intracellular roles in various pathological conditions, including cardiovascular renal disorders, inflammation, and malignancy. In addition to MMP-2, at least eleven other MMPs have been identified to function intracellularly, highlighting the importance of understanding their roles in cellular processes and potential as therapeutic targets.

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G Velasco-Loyden et al.

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Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration

K Endo et al.

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Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils

A Matsuda et al.

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MT1-MMP and MMP-7 in invasion and metastasis of human cancers

T Shiomi et al.

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Branching morphogenesis of the Drosophila tracheal system

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Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13

V Knäuper et al.

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Activation of the proteolytic activity of ADAMTS4 (Aggrecanase-1) by C-terminal truncation

G Gao et al.

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An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase

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Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway

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Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation

T Okamoto et al.

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The function of leak and kuzbanian during growth cone and cell migration

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Upregulated expression of human membrane type-5 matrix metalloproteinase kidneys from diabetic patients

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Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

M Kajita et al.

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Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis

M Pohl et al.

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Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

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