期刊
DEVELOPMENTAL DYNAMICS
卷 251, 期 2, 页码 240-275出版社
WILEY
DOI: 10.1002/dvdy.398
关键词
angiogenesis; axon guidance; cell migration; cell polarity; embryonic development; epithelial-mesenchymal transition; metalloproteinase; synaptogenesis
资金
- Catedra Fundacion ASISA-UE [2019/UEM41]
- Spanish Ministerio de Ciencia, Innovacion y Universidades [SAF2017-83229-R]
- Universidad Europea de Madrid [2018UEM13, 2019UEM10]
MT-MMPs play a role in various processes during embryonic morphogenesis, such as cell migration, proliferation, epithelial-mesenchymal transition, cell polarity and branching, axon growth and navigation, synapse formation, and angiogenesis.
Membrane-type matrix metalloproteinases (MT-MMPs) are cell membrane-tethered proteinases that belong to the family of the MMPs. Apart from their roles in degradation of the extracellular milieu, MT-MMPs are able to activate through proteolytic processing at the cell surface distinct molecules such as receptors, growth factors, cytokines, adhesion molecules, and other pericellular proteins. Although most of the information regarding these enzymes comes from cancer studies, our current knowledge about their contribution in distinct developmental processes occurring in the embryo is limited. In this review, we want to summarize the involvement of MT-MMPs in distinct processes during embryonic morphogenesis, including cell migration and proliferation, epithelial-mesenchymal transition, cell polarity and branching, axon growth and navigation, synapse formation, and angiogenesis. We also considered information about MT-MMP functions from studies assessed in pathological conditions and compared these data with those relevant for embryonic development.
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