期刊
EYE
卷 31, 期 1, 页码 68-86出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2016.198
关键词
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资金
- Fight for Sight UK
- Moorfields Eye Charity
- Choroideremia Research Foundation
- Academy of Medical Sciences
- NIHR Biomedical Research Centre at Moorfields Eye Hospital
- UCL Institute of Ophthalmology
- Academy of Medical Sciences (AMS) [AMS-SGCL7-Moosajee] Funding Source: researchfish
- Fight for Sight [24NE161, 1454/55, 1548/49] Funding Source: researchfish
Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations. Zebra-fish eye development displays in depth mole-cular complexity and stringent spatiotemporal regulation that incorporates developmental contributions of the surface ectoderm, neuroectoderm and head mesenchyme, similar to that seen in humans. For this reason, and due to its genetic tractability, external fertilisation, and early optical clarity, the zebrafish has become an invaluable vertebrate system to investigate human ocular develop-ment and disease. Recently, zebrafish have been at the leading edge of preclinical therapy development, with their amenability to genetic manipulation facilitating the generation of robust ocular disease models required for large- scale genetic and drug screening pro-grammes. This review presents an overview of human and zebrafish ocular development, genetic methodologies employed for zebrafish mutagenesis, relevant models of ocular disease, and finally therapeutic approaches, which may have translational leads in the future.
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