microRNA-132 as a negative regulator in NF-kappa B signaling pathway via targeting IL-1 beta in miiuy croaker

The innate immune system is the first line of defense against the invasion of pathogens. It can make a rapid immune response to the invading pathogenic microorganisms, thereby eliminating the invading pathogens and protecting the body from harm. microRNAs are a family of small non-coding ribonucleic acid molecules, which are important and multifunctional regulator of immune response. In this study, we studied the role of miR-132 as a key regulatory factor of IL-1 beta-mediated inflammation. The seed region of miR-132 can regulate gene expression by binding to the 3'UTR of if -1 beta, and inhibit the expression of IL-1 beta at the post-transcriptional level. More importantly, miR-132 inhibits LPS-induced NF-kappa B signaling pathway by targeting if -1 beta, thereby preventing excessive inflammatory response from causing autoimmune diseases. These results will help to better understand the complex regulatory mechanisms of teleost fishes.

Automated summary

The innate immune system is the first line of defense against pathogens, while microRNA miR-132 plays a crucial role in regulating immune responses, specifically by targeting IL-1 beta to prevent excessive inflammation.