期刊
DERMATOLOGY
卷 238, 期 1, 页码 92-100出版社
KARGER
DOI: 10.1159/000515524
关键词
Autoimmune diseases; Cohort study; Cutaneous lupus erythematosus; Dermatomyositis/polymyositis; Sjogren's syndrome; Systemic lupus erythematosus
类别
资金
- Taichung Veterans General Hospital [10768002C]
CLE-alone patients have an increased risk of developing non-SLE autoimmune diseases in the future, with females and those on long-term systemic corticosteroids being more susceptible to this outcome.
Background: Up to 25% of patients with cutaneous lupus erythematosus (CLE) can develop systemic lupus erythematosus (SLE). However, the risk of autoimmune diseases other than SLE in CLE patients who have only skin manifestations (CLE-alone) has rarely been explored. Objective: To investigate the long-term risk and independent factors of non-SLE autoimmune diseases among CLE-alone patients. Method: A nationwide cohort study using the Taiwanese National Health Insurance Research Database 1997-2013. CLE patients and matched subjects were included. Cumulative incidences of autoimmune diseases after 1 year of CLE-alone diagnosis were compared. Cox proportional hazard model was also performed. Results: A total of 971 CLE-alone patients and 5,175 reference subjects were identified. The 10-year cumulative incidence of autoimmune diseases other than SLE was significantly elevated in the CLE-alone cohort (9.00%, 95% confidence interval [CI] 6.72-11.29) than in the reference cohort (4.20%, 95% CI 3.53-4.87%) (p < 0.001). CLE-alone was independently associated with non-SLE autoimmune diseases (adjusted hazard ratio 1.55, 95% CI 1.10-2.18). Among CLE-alone patients, females and those taking long-term systemic corticosteroids (a proxy for extensive disease) were associated with non-SLE autoimmune diseases after adjusting for the number of repeated autoimmune laboratory tests. Conclusion: CLE-alone is independently associated with future non-SLE autoimmune diseases. (c) 2021 S. Karger AG, Basel
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