期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 21, 期 15, 页码 1377-1397出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026621666210612031144
关键词
Cancer; 1; 3; 4-oxadiazole; Anticancer potential; Synthetic methods; Receptors; Pharmacophore
This paper summarizes the general synthetic methods and anticancer activity of 1,3,4-oxadiazole, discusses the different receptors on which these drugs act, and presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.
Cancer is a kind of human cell degenerative disease that has affected many people for several years. Cancer is caused due to the abnormal growth of cells in every particular part of the body. The 1,3,4-oxadiazole ring is found to be a binding moiety that has anticancer potential. Various works on the 1,3,4-oxadiazole moiety showing anticancer activity have been reported. The present analysis summarizes general synthetic methods for 1,3,4 oxadiazole. Different receptors on which these drug acts are discussed. This review also presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.
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