Synthetic Aspects of Condensed Pyrimidine Derivatives

The present review focuses on the synthesis of two heteroatoms containing six membered heterocyclic compounds, i.e., pyrimidine. In this review, a number of pyrimidine derivatives have been illustrated, which show the exceptional ability towards clinical practices. Pyrimidine derivatives show antimicrobial, antibacterial, antifungal, antiallergic, antiinflammatory, anticancer, and anticonvulsant activities. Therefore, researchers are encouraged to synthesize novel, potent, safe, and selective pyrimidine derivatives that are effective against the mutant strains, and the development of synthetic protocols is a high priority in medicinal chemistry research. Many methodologies have been developed for the preparation of pyrimidine derivatives. In this review article, the synthetic strategies of pyrimidine derivatives are classified into metal-catalyzed synthesis, ionic-liquid assisted synthesis, microwave-assisted synthesis, and solid-phase synthesis.

Automated summary

This review focuses on the synthesis of pyrimidine derivatives with various activities, encouraging researchers to develop novel, potent, safe, and selective compounds against mutant strains. Development of synthetic protocols is a high priority in medicinal chemistry research.