期刊
CURRENT ORGANIC CHEMISTRY
卷 25, 期 19, 页码 2199-2216出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272825666210728101125
关键词
Amines; amination; chemoselectivity; enantioselectivity; catalysis; hypervalent compounds; synthetic methods
资金
- FCT [SFRH/BD/116322/2016, PD/BD/142864/2018]
- Associate Laboratory for Green Chemistry-LAQV - FCT/MCTES [UID/QUI/50006/2019]
- ERDF under the PT2020 Partnership Agreement [POCI-01-0145-FEDER - 007265]
- Fundação para a Ciência e a Tecnologia [PD/BD/142864/2018, SFRH/BD/116322/2016] Funding Source: FCT
In recent years, there has been a significant increase in the number of protocols for alpha-amination of carbonyl compounds, emphasizing the importance of this functional group. While classical approaches are still being used, new methods with unique advantages, such as the use of umpoled enolates, generation of electrophilic nitrogen sources, and oxidative methods, have also emerged.
In the past few years, the number of protocols for alpha-amination of carbonyl compounds has dramatically increased, highlighting the importance of this moiety. While some classical approaches continue to be used, supported by novel catalysts, new methods with unique advantages have also emerged. Among these, a wide variety of conditions can be observed, such as the use of umpoled enolates with nucleophilic nitrogen sources, the generation of electrophilic nitrogen sources, and oxidative methods, generally through the generation of radical species. This review aims to compile the most recent publications for the alpha-amination of carbonyls on the basis of synthetic utility, novel transformations, and enantioselectivity.
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