期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 69, 期 -, 页码 150-159出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2021.04.005
关键词
Receptor signaling; GPCRs; Structural dynamics; Web resources; Computational biology
资金
- Spanish Ministry of Science, Innovation and Universities [FPU16/01209]
- National Center of Science, Poland [2017/27/N/NZ2/02571]
- Lundbeck foundation [R163-2013-16327]
- Novo Nordisk Foundation [NNF18OC0031226]
- Instituto de Salud Carlos III FEDER [PI15/00460, PI18/00094]
- ERA-NET NEURON & Ministry of Economy, Industry and Competitiveness [AC18/00030]
G protein-coupled receptors are crucial in human physiological processes and are affected by genetic encoding and sequence diversity. Understanding the link between protein sequence, structure, and function is essential for interpreting the physiological response of GPCRs.
G protein-coupled receptors (GPCRs) are implicated in nearly all physiological processes in the human body and represent an important drug targeting class. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by natural genetic variants and isoforms. Deciphering the molecular link between sequence diversity and its functional consequences is a current challenge and critical for the comprehension of the physiological response of GPCRs. It requires a global understanding of how protein sequence translates into protein structure, how this impacts the structural motions of the protein, and, finally, how all these factors determine the receptor functionality. Here, we discuss available resources and state-of-the-art computational approaches to address this question.
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