4.4 Review

Updates on interferon in juvenile dermatomyositis: pathogenesis and therapy

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Review Rheumatology

Successful management with Janus kinase inhibitor tofacitinib in refractory juvenile dermatomyositis: a pilot study and literature review

Zhongxun Yu et al.

Summary: This study investigated the use of tofacitinib in refractory JDM cases, showing promising results in terms of tolerance and efficacy for the three patients studied. Tofacitinib was well-tolerated and led to significant improvement in disease activity, suggesting it may be a potential treatment option for refractory JDM cases.

RHEUMATOLOGY (2021)

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Comparison of Lesional Juvenile Myositis and Lupus Skin Reveals Overlapping Yet Unique Disease Pathophysiology

Jessica L. Turnier et al.

Summary: Skin inflammation in juvenile myositis is characterized by up-regulation of interferon-stimulated genes, with a gene expression pattern similar to childhood-onset SLE. Patients with juvenile myositis positive for NXP-2 autoantibodies exhibit the strongest IFN signature, suggesting a potential link to disease endotypes and pathogenesis.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Rheumatology

From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies

Cyrielle Hou et al.

Summary: The expression of ISG15 is closely associated with juvenile DM, with patients exhibiting different ISG15 muscle signatures according to their MSA class. Patients with juvenile DM who are positive for MDA-5 have higher levels of ISG15 expression in both gene and protein form compared to other subgroups. Additionally, the data shows that negative regulation of type I IFN correlates with milder muscle involvement.

ARTHRITIS & RHEUMATOLOGY (2021)

Letter Rheumatology

Janus kinase inhibitor significantly improved rash and muscle strength in juvenile dermatomyositis

Yuchuan Ding et al.

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Article Medicine, Research & Experimental

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

Adriana A. de Jesus et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Interferon-Stimulated Genes: What Do They All Do?

John W. Schoggins

ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019 (2019)

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The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family

Hideo Negishi et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

Gina A. Montealegre Sanchez et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Development of a Validated Interferon Score Using NanoString Technology

Hanna Kim et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2018)

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Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

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JOURNAL OF LEUKOCYTE BIOLOGY (2018)

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Update on outcome assessment in myositis

Lisa G. Rider et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

Review Rheumatology

Risk factors and disease mechanisms in myositis

Frederick W. Miller et al.

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Review Rheumatology

Medications received by patients with juvenile dermatomyositis

Takayuki Kishi et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2018)

Letter Clinical Neurology

A child with severe juvenile dermatomyositis treated with ruxolitinib

Florence A. Aeschlimann et al.

Article Immunology

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

Mathieu P. Rodero et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositis

Noemi De Luna et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, General & Internal

The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes

L. G. Rider et al.

JOURNAL OF INTERNAL MEDICINE (2016)

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Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus

Hanna Kim et al.

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Review Biochemistry & Molecular Biology

New perspectives on type I IFNs in cancer

Thomas F. Gajewski et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Article Rheumatology

Whole microvascular unit deletions in dermatomyositis

Cyril Gitiaux et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

Review Rheumatology

Juvenile dermatomyositis: new insights and new treatment strategies

Neil Martin et al.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2012)

Review Rheumatology

Type I interferon pathway in adult and juvenile dermatomyositis

Emily C. Baechler et al.

ARTHRITIS RESEARCH & THERAPY (2011)

Article Biochemistry & Molecular Biology

An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity

Emily C. Baechler et al.

MOLECULAR MEDICINE (2007)

Article Pediatrics

Elevated serum levels of soluble interleukin-2 receptor in juvenile dermatomyositis

I Kobayashi et al.

PEDIATRICS INTERNATIONAL (2001)