期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 69, 期 -, 页码 159-169出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2021.02.009
关键词
Connectomics; Genomics; Microscopy; Super-resolution imaging; Optogenetic tools; Chemogenetic tools; Motor circuit; Neuro-gut axis; Neuromodulation
资金
- NIH [R37 NS 035546]
The completion of Caenorhabditis elegans connectomics four decades ago has guided mechanistic investigation of neuronal circuits. Recent technological advances have aided re-examination of this connectomics, uncovering previously unreported synaptic connections and generating models for neural networks underlying behaviors. Combining molecular information and cell-specific manipulation tools has enhanced the ability to investigate individual neurons in behaving animals precisely.
The completion of Caenorhabditis elegans connectomics four decades ago has long guided mechanistic investigation of neuronal circuits. Recent technological advances in microscopy and computation programs have aided re-examination of this connectomics, expanding our knowledge by both uncovering previously unreported synaptic connections and also generating models for neural networks underlying behaviors. Combining molecular information from single cell transcriptomes with elegant tools for cell-specific manipulation has further enhanced the ability to precisely investigate individual neurons in behaving animals. This mini-review aims to provide an overview of new information on connectomics and progress toward a molecular atlas of C. elegans nervous system, and discuss emerging findings on neuronal circuits.
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