期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 63, 期 -, 页码 11-18出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2021.01.011
关键词
Metabolism; Chromatin; Epigenetics; Transcription; Methionine
资金
- National Institutes of Health [R01CA193256]
- American Cancer Society [RSG-16-214-01-TBE]
Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures. Studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure are largely unknown.
Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures, including physiological stress, nutritional deprivation, and starvation. Numerous studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure (e.g. chromatin compaction, nucleosome arrangement, and chromatin loops) and how they appropriately deposit specific chemical modification on chromatin are largely unknown. Here, focusing on methionine metabolism, we discuss recent developments of metabolic effects on chromatin modifications and structure, as well as consequences on gene regulation.
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