4.5 Review

Intrinsically disordered proteins and biomolecular condensates as drug targets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
News Item Biotechnology & Applied Microbiology

Drug startups coalesce around condensates

Elie Dolgin

NATURE BIOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Targeting intrinsically disordered proteins involved in cancer

Patricia Santofimia-Castano et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Biochemistry & Molecular Biology

Molecular structure in biomolecular condensates

Ivan Peran et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

Article Chemistry, Medicinal

Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations

Pablo Herrera-Nieto et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

Article Multidisciplinary Sciences

Partitioning of cancer therapeutics in nuclear condensates

Isaac A. Klein et al.

SCIENCE (2020)

Review Multidisciplinary Sciences

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

Cecile Mathieu et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

Gabriella T. Heller et al.

SCIENCE ADVANCES (2020)

Article Multidisciplinary Sciences

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

W. Michael Babinchak et al.

NATURE COMMUNICATIONS (2020)

Review Pharmacology & Pharmacy

Targeting intrinsically disordered proteins at the edge of chaos

Hao Ruan et al.

DRUG DISCOVERY TODAY (2019)

Article Medicine, Research & Experimental

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castano et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Oncology

The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents

Filippo Spriano et al.

CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Genetics & Heredity

Liquid–Liquid Phase Separation in Disease

Simon Alberti et al.

Annual Review of Genetics (2019)

Article Multidisciplinary Sciences

Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2

Min Young Kim et al.

SCIENCE ADVANCES (2019)

Review Oncology

Targeting transcription factors in cancer - from undruggable to reality

John H. Bushweller

NATURE REVIEWS CANCER (2019)

Review Biochemistry & Molecular Biology

Cryptic binding sites on proteins: definition, detection, and druggability

Sandor Vajda et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm

K. Tsafou et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

Gabriella T. Heller et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

Self-interaction of NPM1 modulates multiple mechanisms of liquid-liquid phase separation

Diana M. Mitrea et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Who's In and Who's Out-Compositional Control of Biomolecular Condensates

Jonathon A. Ditlev et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Physics, Multidisciplinary

Growth and division of active droplets provides a model for protocells

David Zwicker et al.

NATURE PHYSICS (2017)

Article Biochemistry & Molecular Biology

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

Gabriella T. Heller et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Article Chemistry, Multidisciplinary

A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein

David Ban et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Review Cell Biology

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

Jacob P. Brady et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

ATP as a biological hydrotrope

Avinash Patel et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule

Seung H. Choi et al.

ACS CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin

Jeffrey B. Woodruff et al.

Review Biochemistry & Molecular Biology

The Multiple Faces of Disordered Nucleoporins

Edward A. Lemke

JOURNAL OF MOLECULAR BIOLOGY (2016)

Article Chemistry, Multidisciplinary

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

Timothy J. Nott et al.

NATURE CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

H. Broder Schmidt et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Neurosciences

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease

Lars Tatenhorst et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

Chen Yu et al.

SCIENTIFIC REPORTS (2016)

Article Behavioral Sciences

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Valeria Melisa et al.

BEHAVIOURAL PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Avinash Patel et al.

Article Biochemistry & Molecular Biology

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

Timothy J. Nott et al.

MOLECULAR CELL (2015)

Review Cell Biology

Intrinsically disordered proteins in cellular signalling and regulation

Peter E. Wright et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Targeting disordered proteins with small molecules using entropy

Gabriella T. Heller et al.

TRENDS IN BIOCHEMICAL SCIENCES (2015)

Article Multidisciplinary Sciences

Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1

Luigi I. Iconaru et al.

SCIENTIFIC REPORTS (2015)

Review Cell Biology

Liquid-Liquid Phase Separation in Biology

Anthony A. Hyman et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Clinical Neurology

Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease

Eugene O'Hare et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2014)

Review Virology

DNA Virus Replication Compartments

Melanie Schmid et al.

JOURNAL OF VIROLOGY (2014)

Article Biochemistry & Molecular Biology

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

Navasona Krishnan et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Multidisciplinary Sciences

Inhibitor of MYC identified in a Krohnke pyridine library

Jonathan R. Hart et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Pharmacology & Pharmacy

Chemical kinetics for drug discovery to combat protein aggregation diseases

Paolo Arosio et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Medicine, Research & Experimental

An androgen receptor N-terminal domain antagonist for treating prostate cancer

Jae-Kyung Myung et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemical Research Methods

Ligand Clouds around Protein Clouds: A Scenario of Ligand Binding with Intrinsically Disordered Proteins

Fan Jin et al.

PLOS COMPUTATIONAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

The Amyloid State of Proteins in Human Diseases

David Eisenberg et al.

Review Biochemistry & Molecular Biology

Electrophilic natural products and their biological targets

Malte Gersch et al.

NATURAL PRODUCT REPORTS (2012)

Review Pharmacology & Pharmacy

Structure-based drug design to augment hit discovery

Subha Kalyaanamoorthy et al.

DRUG DISCOVERY TODAY (2011)

Review Biophysics

Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles

R. Bryn Fenwick et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2011)

Article Chemistry, Multidisciplinary

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

Andrew J. Baldwin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biophysics

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

Joseph A. Marsh et al.

BIOPHYSICAL JOURNAL (2010)

Review Biochemistry & Molecular Biology

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

Stephen Connelly et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)

Article Chemistry, Medicinal

Small-molecule perturbation of competing interactions between c-Myc and Max

Ariele Viacava Follis et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Biochemistry & Molecular Biology

Linking folding and binding

Peter E. Wright et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

Wenkai Li et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

Dalia I. Hammoudeh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Biochemistry & Molecular Biology

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Ariele Viacava Follis et al.

CHEMISTRY & BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules

Anke Kiessling et al.

CHEMISTRY & BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors

N Issaeva et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils

M Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Low molecular weight inhibitors of Myc-Max interaction and function

XY Yin et al.

ONCOGENE (2003)