期刊
CURRENT OPINION IN CELL BIOLOGY
卷 70, 期 -, 页码 10-17出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.10.015
关键词
Chromatin; Histone modifications; DNA methylation; Epigenetics
类别
资金
- Swiss National Science Foundation, Switzerland [PP00P3_183722, CRSII5_180345, CRSK-3_190378]
- European Research Council [865094 -ChromatinLEGO -ERC-2019-COG]
- EMBO Young Investigator program
- Swiss National Science Foundation (SNF) [CRSII5_180345, CRSK-3_190378, PP00P3_183722] Funding Source: Swiss National Science Foundation (SNF)
Nucleosomes are basic structures used to package genetic information, subject to diverse chemical modifications. These modifications serve as interaction hubs for nuclear proteins, ensuring correct deposition to the genome. The regulation of chromatin marks relies on coordinated activities of writer, eraser, and reader enzymes, often depending on complex multicomponent regulatory circuits.
Nucleosomes, the basic structures used to package genetic information into chromatin, are subject to a diverse array of chemical modifications. A large number of these marks serve as interaction hubs for many nuclear proteins and provide critical structural features for protein recruitment. Dynamic deposition and removal of chromatin modifications by regulatory proteins ensure their correct deposition to the genome, which is essential for DNA replication, transcription, chromatin compaction, or DNA damage repair. The spatiotemporal regulation and maintenance of chromatin marks relies on coordinated activities of writer, eraser, and reader enzymes and often depends on complex multicomponent regulatory circuits. In recent years, the field has made enormous advances in uncovering the mechanisms that regulate chromatin modifications. Here, we discuss well-established and emerging concepts in chromatin biology ranging from cooperativity and multivalent interactions to regulatory feedback loops and increased local concentration of chromatin-modifying enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据