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Bioproduction of biomacromolecules for antiviral applications

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CURRENT OPINION IN BIOTECHNOLOGY
卷 69, 期 -, 页码 263-272

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ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.01.022

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资金

  1. National Science Foundation [2028763, 2036768]
  2. Direct For Biological Sciences
  3. Div Of Molecular and Cellular Bioscience [2036768] Funding Source: National Science Foundation
  4. Directorate For Engineering
  5. Div Of Chem, Bioeng, Env, & Transp Sys [2028763] Funding Source: National Science Foundation

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Research suggests the necessity to develop and deploy next-generation antiviral treatments, with biomacromolecules potentially serving as potent antiviral agents. Modern advances in technology can enable the production of tailored biomacromolecules for targeted antiviral applications.
The societal damage brought on by viral epidemics indicates that next-generation antiviral treatments must be developed and deployed. Biomacromolecules are a diverse class of compounds that can potentially exhibit potent antiviral activity. Their efficacy and mechanisms of action are dependent upon multiple structural factors, including molecular weight, degree and position of sulfation, and backbone stereochemistry. Extracting biomacromolecules from animals and plants for healthcare applications is undesirable, as these methods are unable to yield products with well-defined chemical structures. Modern advances utilizing recombinant microbes and metabolic pathway engineering can be a key step towards large-scale bioproduction of tailored biomacromolecules for targeted antiviral applications.

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