期刊
CURRENT NEUROPHARMACOLOGY
卷 20, 期 3, 页码 550-559出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X19666210712153329
关键词
Zebrafish; American traditional medicine; behavior; brain effects; drug screening; animal models
资金
- Southwest University Zebrafish Platform Construction Funds (Chongqing, China)
- CNPq [305051/2018-0]
- FAPERGS Gaucho Researcher Program -PQG fellowship [19/2551-0001764-2]
- FAPERGS [19/2551-0001-669-7]
- Sirius University (Sochi, Russia)
- Russian Science Foundation (RSF) [20-65-46006]
- Resource Fund of Applied Genetics MIPT [075-15-2021-684]
- Russian Science Foundation [20-65-46006] Funding Source: Russian Science Foundation
Although traditional medicine has been practiced for a long time, its therapeutic mechanisms are not fully understood. This study highlights the importance of using zebrafish as a model organism to study the neurotropic effects of traditional medicine and their potential in treating brain disorders.
Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
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