Effect of Serum Albumin, a Component of Human Pleural Fluid, on Transcriptional and Phenotypic Changes on Acinetobacter baumannii A118

Article Microbiology

AbaM Regulates Quorum Sensing, Biofilm Formation, and Virulence in Acinetobacter baumannii

Mario Lopez-Martin et al.

Summary: The research demonstrates that the gene abaM plays a central role in regulating QS, virulence, surface motility, and biofilm formation in A. baumannii strains, with mutations leading to increased AHL production and enhanced biofilm formation, but decreased virulence.

JOURNAL OF BACTERIOLOGY (2021)

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Article Multidisciplinary Sciences

Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii

Jasmine Martinez et al.

Summary: This study investigates the genetic changes and virulence factor expression of Acinetobacter baumannii in the cerebrospinal fluid (CSF) environment, showing its adaptability and survival capabilities. While a highly virulent strain showed no transcriptome changes in the presence of CSF, a low-virulence isolate exhibited significant differences in gene expression. Exposure to CSF induced increased expression of virulence factors without promoting bacterial growth, but rather increasing the expression of genes associated with transcription, translation, and ATP synthesis.

SCIENTIFIC REPORTS (2021)

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Article Microbiology

Human Pleural Fluid and Human Serum Albumin Modulate the Behavior of a Hypervirulent and Multidrug-Resistant (MDR) Acinetobacter baumannii Representative Strain

Camila Pimentel et al.

Summary: Acinetobacter baumannii, a nosocomial pathogen with high antibiotic resistance, has been shown to adapt to different host environments, providing insights into potential novel antimicrobial strategies. Research on the gene expression profile of A. baumannii when exposed to human fluids revealed key pathways involved in the pathogen's response.

PATHOGENS (2021)

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Article Microbiology