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First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone
Johannes Nagelschmitz et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate
N. P. Dhammika Nanayakkara et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
Margaret A. Phillips et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Investigation of the redox behavior of ferroquine, a new antimalarial
Natascha Chavain et al.
MOLECULAR PHARMACEUTICS (2008)
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
Harald Noedl et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
David Plouffe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)
Marcel Kaiser et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo
L. Vivas et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
The effects of anti-bacterials on the malaria parasite Plasmodium falciparum
Christopher Dean Goodman et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2007)
Mechanism of antimalarial action of the synthetic trioxoane RBX11160 (OZ277)
Anne-Catrin Uhlemann et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Evaluation and lead optimization of anti-malarial acridones
Rolf W. Winter et al.
EXPERIMENTAL PARASITOLOGY (2006)
Tetracyclines specifically target the picoplast of the malaria parasite Plasmodium falciparum
Erica L. Dahl et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
Amar Bir Singh Sidhu et al.
JOURNAL OF INFECTIOUS DISEASES (2006)
In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum
W Daher et al.
DRUG METABOLISM AND DISPOSITION (2006)
Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure
W Daher et al.
MALARIA JOURNAL (2006)
The past, present and future of antifolates in the treatment of Plasmodium falciparum infection
Alexis Nzila
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
Artemisone - A highly active antimalarial drug of the artemisinin class
RK Haynes et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs
Paul M. O'Neill et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes
YX Dong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
C Sisowath et al.
JOURNAL OF INFECTIOUS DISEASES (2005)
Piperaquine - A resurgent antimalarial drug
TME Davis et al.
DRUGS (2005)
Sulfonyl-phenyl-ureido benzamidines: a novel structural class of potent antimalarial agents
J Leban et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Identification of an antimalarial synthetic trioxolane drug development candidate
JL Vennerstrom et al.
NATURE (2004)
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
RN Price et al.
LANCET (2004)
Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques
S Ramanathan-Girish et al.
INTERNATIONAL JOURNAL OF TOXICOLOGY (2004)
Artemisinins target the SERCA of Plasmodium falciparum
U Eckstein-Ludwig et al.
NATURE (2003)
Insights into antifolate resistance from malarial DHFR-TS structures
J Yuvaniyama et al.
NATURE STRUCTURAL BIOLOGY (2003)
New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins
SP Jiang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites
L Delhaes et al.
PARASITOLOGY RESEARCH (2001)