期刊
CURRENT BIOLOGY
卷 31, 期 21, 页码 4689-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2021.08.020
关键词
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资金
- Biotechnology and Biological Science Research Council (BBSRC) [BB/M011224/1]
- OxfordRadcliffe gradate scholarship from University College, Oxford
This study provides a predictive mechanistic model to explain the rate decay phenomenon of viruses and successfully applies it to re-estimate the date of diversification of hepatitis C virus genotypes, as well as the origin time of the most recent common ancestor of sarbecoviruses. By studying the evolutionary processes of viruses, it offers a new perspective for us to understand the origins of these viruses.
Estimating viral timescales is fundamental in understanding the evolutionary biology of viruses. Molecular clocks are widely used to reveal the recent evolutionary histories of viruses but may severely underestimate their longer-term origins because of the inverse correlation between inferred rates of evolution and the timescale of their measurement. Here, we provide a predictive mechanistic model that readily explains the rate decay phenomenon over a wide range of timescales and recapitulates the ubiquitous power-law rate decay with a slope of similar to 0.65. We show that standard substitution models fail to correctly estimate divergence times once the most rapidly evolving sites saturate, typically after hundreds of years in RNA viruses and thousands of years in DNA viruses. Our model successfully recreates the observed pattern of decay and explains the evolutionary processes behind the time-dependent rate phenomenon. We then apply our model to re-estimate the date of diversification of genotypes of hepatitis C virus to 423,000 (95% highest posterior density [HPD]: 394,000-454,000) years before present, a time preceding the dispersal of modern humans out of Africa, and show that the most recent common ancestor of sarbecoviruses dates back to 21,000 (95% HPD: 19,000-22,000) years ago, nearly thirty times older than previous estimates. This creates a new perspective for our understanding of the origins of these viruses and also suggests that a substantial revision of evolutionary timescales of other viruses can be similarly achieved.
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