Cytoskeletal biophysics: Passive crosslinker adapts to keep microtubule bundles on track

Assembly of the mitotic spindle requires dynamic adaptation and coordination among an array of motors and crosslinkers. A new study demonstrates in vitro how the mitotic crosslinker PRC1 can tune its behavior to regulate the speed of microtubule sliding.

Automated summary

The study shows how the mitotic crosslinker PRC1 can adjust its behavior to regulate the speed of microtubule sliding, contributing to the assembly of the mitotic spindle.