Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities

Head and neck cancer is globally challenging due to the resistance to therapy and aggressive behavior leading to high rates of mortality. Recent findings show that the tumor microenvironment plays a role in the maintenance and progression of many solid tumors, including head and neck cancer. The mechanisms involved in the modulation and regulation of the tumor microenvironment remain poorly understood. Increasing evidence suggests that epigenetic events can modulate the crosstalk between neoplastic and non-neoplastic cells during tumor progression. In this review, we explore the current understanding of the involvement of epigenetic events in the modulation of the tumor microenvironment and its impact on head and neck cancer behavior. We also explore the latest therapeutic strategies that use epigenetic-modulating drugs to manage tumor growth and progression.

Automated summary

Head and neck cancer poses a global challenge with resistance to therapy and aggressive behavior. The tumor microenvironment and epigenetic events play crucial roles in the development of this cancer, offering potential new strategies for treatment. Further research into the modulation of the tumor microenvironment and epigenetic events could lead to innovative therapeutic approaches for managing head and neck cancer.