期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 164, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2021.103428
关键词
Colorectal cancer; Consensus molecular subtypes; Gastric cancer; Pancreatic cancer
资金
- New York Stem Cell Foundation
- KWF [UVA2014-7245, 10529]
- Maurits en Anna de Kock Stichting [2015-2]
- European Research Council [ERG-StG 638193, ERC-PoC 841112]
- ZonMw [Vidi 016.156.308]
The study investigated molecular subtypes across colorectal cancer, pancreatic ductal adenocarcinoma, and gastric cancer, identifying four categories of subtypes with overlapping molecular features and clinical outcomes. This finding encourages quantitative studies on subtypes across different cancer types and could lead to a paradigm shift in future treatment strategies.
In colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC) multiple studies of inter-tumor heterogeneity have identified molecular subtypes, which correlate with clinical features. Our aim was to investigate the attributes of molecular subtypes across three different gastrointestinal cancer types. We performed a systematic search for publications on molecular subtypes or classifications in PDAC and GC and compared the described subtypes with the established consensus molecular subtypes of CRC. Examining the characteristics of subtypes across CRC, PDAC and GC resulted in four categories of subtypes. We describe uniting and distinguishing features within a mesenchymal, an epithelial, an immunogenic and a metabolic and digestive subtype category. We conclude that molecular subtypes of CRC, PDAC and GC display relevant overlap in molecular features and clinical outcomes. This finding encourages quantitative studies on subtypes across different cancer types and could lead to a paradigm shift in future treatment strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据