Hepatotoxicity of food-borne mycotoxins: molecular mechanism, anti-hepatotoxic medicines and target prediction

Mycotoxins are metabolites produced by fungi. The widespread contamination of food and feed by mycotoxins is a global food safety problem and a serious threat to people's health. Most food-borne mycotoxins have strong hepatotoxicity. However, no effective methods have been found to prevent or treat Mycotoxin- Induced Liver Injury (MILI) in clinical and animal husbandry. In this paper, the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI are reviewed, and their targets are predicted by network toxicology, which provides a theoretical basis for further study of the toxicity mechanism of MILI and the development of effective strategies to manage MILI-related health problems in the future and accelerate the development of food safety.

Automated summary

Mycotoxins, produced by fungi, pose a global food safety problem and a serious threat to health due to their hepatotoxicity. This paper reviews the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI, predicting their targets through network toxicology to provide a theoretical basis for studying MILI toxicity mechanisms and developing effective strategies for managing MILI-related health issues in the future, ultimately accelerating food safety development.