期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 62, 期 9, 页码 2281-2308出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2021.1960794
关键词
Anti-hepatotoxic medicines; hepatotoxicity; molecular mechanism; mycotoxins; target prediction
资金
- National Natural Science Foundation of China [81872999]
- CAMS Innovation Fund for Medical Sciences [2017-I2M-1-013]
- Foreign Experts Project [G20200001511]
Mycotoxins, produced by fungi, pose a global food safety problem and a serious threat to health due to their hepatotoxicity. This paper reviews the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI, predicting their targets through network toxicology to provide a theoretical basis for studying MILI toxicity mechanisms and developing effective strategies for managing MILI-related health issues in the future, ultimately accelerating food safety development.
Mycotoxins are metabolites produced by fungi. The widespread contamination of food and feed by mycotoxins is a global food safety problem and a serious threat to people's health. Most food-borne mycotoxins have strong hepatotoxicity. However, no effective methods have been found to prevent or treat Mycotoxin- Induced Liver Injury (MILI) in clinical and animal husbandry. In this paper, the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI are reviewed, and their targets are predicted by network toxicology, which provides a theoretical basis for further study of the toxicity mechanism of MILI and the development of effective strategies to manage MILI-related health problems in the future and accelerate the development of food safety.
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