The structural appeal of metal-organic frameworks in antimicrobial applications

Diseases caused by microorganisms have significantly impacted public health. Metal-organic frameworks (MOFs) and MOF-based materials with unique physical and chemical properties have shown promise as candidates for potent antimicrobial agents. In this review, the structural characteristics of MOFs that are demonstrated to be the main structural determinants in microorganism inactivation are discussed, with a particular focus on the type(s) of metal clusters, organic ligands, nanoparticles, and pores employed. A comprehensive overview of antimicrobial applications of MOFs and MOF-based composites on wound dressings, nano-pharmaceuticals, protective materials, antimicrobial surfaces, food preservation, and environmental decontamination will be presented in terms of these four structural elements. Last but not least, the future prospects of MOFs in antimicrobial applications as well as potential opportunities and challenges, are also elaborated. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Diseases caused by microorganisms have had a significant impact on public health. Metal-organic frameworks (MOFs) and MOF-based materials, with unique physical and chemical properties, are considered promising candidates for potent antimicrobial agents. This review discusses the structural characteristics of MOFs that play a key role in microorganism inactivation, focusing on the types of metal clusters, organic ligands, nanoparticles, and pores used. The review provides an overview of the antimicrobial applications of MOFs in various fields, along with discussing the future prospects and potential challenges.