期刊
COORDINATION CHEMISTRY REVIEWS
卷 443, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2021.214016
关键词
Ruthenium(II); Iridium(III); Nanomaterials; Anticancer; Bioimaging
资金
- National Natural Science Foundation of China, China [21525105, 21778079]
- Fundamental Research Funds for the Central Universities of China, China [20lgjc01]
This review explores the fabrication strategies and potential applications of Ru(II) and Ir(III) complex containing nanosystems, highlighting their recent developments in cancer treatment and bioimaging. Challenges and opportunities in this field are also discussed for future research.
Ruthenium(II) and iridium(III) coordination compounds display excellent structural, photophysical, and biological properties which make them highly promising as anticancer and bioimaging agents. When nanoparticles are functionalized with Ru(II) and Ir(III) complexes, enhanced performance and synergistic effects can be produced in the resultant nanosystems. This review begins by describing the three main strategies for the fabrication of Ru(II) and Ir(III) complex containing nanosystems. This is followed by a discussion of the ways in which Ru(II) and Ir(III) complexes and nanoparticles combine and interact to produce novel materials with efficacies exceeding the sum of their parts. The main body of the review then outlines the recent developments in Ru(II) and Ir(III) complex containing nanosystems for cancer treatment and bioimaging. To conclude, some of the future challenges and opportunities in this field are highlighted. (C) 2021 Elsevier B.V. All rights reserved.
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