期刊
COMPUTATIONAL BIOLOGY AND CHEMISTRY
卷 92, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.compbiolchem.2021.107478
关键词
Protein-protein interaction; Astrocyte elevated gene-1; Transcription factor; Interaction network; Localization; Pathways
资金
- Department of Science and Technology (DST) - Science and Engineering Research Board (SERB) [EMR/2017/001877]
- Lady Tata Memorial Trust (LTMT)
This study analyzed the biological functions, pathways, and interactions of AEG-1 and its interacting proteins using bioinformatic tools, revealing the crosstalk and regulatory network between them.
Multifunctional in nature, the protein Astrocyte Elevated Gene-1 (AEG-1) controls several cancers through protein-protein interactions. Although, specific physiological processes and molecular functions linked with AEG-1 interactors remain unclear. In our present study, we procured the data of AEG-1 interacting proteins and evaluated their biological functions, associated pathways, and interaction networks using bioinformatic tools. A total of 112 proteins experimentally detected to interact with AEG-1 were collected from various public databases. DAVID 6.8 Online tool was utilized to identify the molecular functions, biological processes, cellular components that aid in understanding the physiological function of AEG-1 and its interactors in several cell types. With the help of integrated network analysis of AEG-1 interactors using Cytoscape 3.8.0 software, crosstalk between various proteins, and associated pathways were revealed. Additionally, the Enrichr online tool was used for performing enrichment of transcription factors of AEG-1 interactors' which further revealed a closely associated self-regulated interaction network of a variety of transcription factors that shape the expression of AEG-1 interacting proteins. As a whole, the study calls for better understanding and elucidation of the pathways and biological roles of both AEG-1 and its interactor proteins that might enable their application as biomarkers and therapeutic targets in various diseases in the very near future.
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