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Slow digestion-oriented dietary strategy to sustain the secretion of GLP-1 for improved glucose homeostasis

期刊

出版社

WILEY
DOI: 10.1111/1541-4337.12808

关键词

dietary approach; glucagon-like peptide-1 (GLP-1); glucose homeostasis; slow digestion

资金

  1. National Natural Science Foundation of China [31471585]

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Efficiently reducing the digestion rate of food nutrients through a slow digestion-oriented dietary approach can potentiate distal deposition and sustained secretion of GLP-1, which is beneficial for improved glucose homeostasis and health.
Dysregulated glucose metabolism is associated with many chronic diseases such as obesity and type 2 diabetes mellitus (T2DM), and strategies to restore and maintain glucose homeostasis are essential to health. The incretin hormone of glucagon-like peptide-1 (GLP-1) is known to play a critical role in regulating glucose homeostasis and dietary nutrients are the primary stimuli to the release of intestinal GLP-1. However, the GLP-1 producing enteroendocrine L-cells are mainly distributed in the distal region of the gastrointestinal tract where there are almost no nutrients to stimulate the secretion of GLP-1 under normal situations. Thus, a dietary strategy to sustain the release of GLP-1 was proposed, and the slow digestion property and dipeptidyl peptidase IV (DPP-IV) inhibitory activity of food components, approaches to reduce the rate of food digestion, and mechanisms to sustain the release of GLP-1 were reviewed. A slow digestion-oriented dietary approach through encapsulation of nutrients, incorporation of viscous dietary fibers, and enzyme inhibitors of phytochemicals in a designed whole food matrix will be implemented to efficiently reduce the digestion rate of food nutrients, potentiate their distal deposition and a sustained secretion of GLP-1, which will be beneficial to improved glucose homeostasis and health.

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