期刊
EXPERT REVIEW OF VACCINES
卷 15, 期 6, 页码 709-717出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2016.1147354
关键词
HIV vaccine; CD4 T cells; HIV susceptibility; antigen specificity; pathogenesis
类别
资金
- NIH [R21AI110214]
- Robert Mapplethorpe Foundation
HIV causes infection and progressive depletion of human CD4 T cells. Emerging data have shown that antigen-specific CD4 T-cell subsets manifest differential susceptibility to HIV, potentially leading to pathogen-specific immune failure and opportunistic infections. This concept was recently explored in context of vectors utilized in HIV vaccine trials, and the data suggest that adenovirus type 5(Ad5)-specific CD4 T cells elicited by Ad5-HIV vaccine may be particularly susceptible to HIV, potentially rendering Ad5 vaccine recipients susceptible to HIV acquisition. We here examined recent data regarding the HIV susceptibility of antigen-specific CD4 T cells induced during infection or HIV vaccination and discussed its potential impact on HIV acquisition risk posed by HIV vaccination.
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