期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
卷 39, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbd.2021.100861
关键词
G protein-coupled receptor; Whole genome; Minute rotifer; Proales similis
资金
- National Research Foundation [2020R1F1A1076854]
- Collaborative Genome Program of the Korea Institute ofMarine Science and Technology Promotion - Ministry of Oceans and Fisheries [20180430]
- National Research Foundation of Korea [2020R1F1A1076854] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study assembled the whole-genome sequence of the minute marine rotifer Proales similis, identified and classified GPCR genes, and revealed new insights into ligand-receptor signaling pathways in response to environmental cues, as well as the evolution of GPCRs in P. similis.
The minute marine rotifer Proales similis is a potential model species for ecotoxicological and ecophysiological studies. Therefore, the provision of whole-genome data for P. similis is an easy way to deepen understanding of the molecular mechanisms involved in response to various environmental stressors. In this research, we assembled the whole-genome sequence (32.7 Mb total, N50 = 2.42 Mb) of P. similis, consisting of 15 contigs with 10,785 annotated genes. To understand the ligand-receptor signaling pathway in rotifers in response to environmental cues, we identified 401 G protein-coupled receptor (GPCR) genes in the P. similis genome and compared them with those from other species. The 401 full-length GPCR genes were classified into five distinct classes: A (363), B (18), C (7), F (2), and other (11). Most GPCR gene families have undergone sporadic evolutionary processes. However, some classes were highly conserved between species. Overall, this result provides new information about GPCR-based signaling pathways and the evolution of GPCRs in the minute rotifer P. similis, and it expands our knowledge of ligand-receptor signaling pathways in response to various environmental cues.
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