期刊
EXPERT REVIEW OF VACCINES
卷 15, 期 8, 页码 977-988出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2016.1161510
关键词
Chlamydia; vaccine; antigen; adjuvant; tissue-resident memory T cells; immunoproteomics
类别
资金
- National Institute of Allergy and Infectious Diseases [R01AI076483]
- Genome BC
- Western Economic Diversification
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI076483, R01AI113103] Funding Source: NIH RePORTER
Chlamydia trachomatis is the most common preventable cause of tubal infertility in women. In high-income countries, despite public health control efforts, C. trachomatis case rates continue to rise. Most medium and low-income countries lack any Chlamydia control program; therefore, a vaccine is essential for the control of Chlamydia infections. A rationally designed Chlamydia vaccine requires understanding of the immunological correlates of protective immunity, pathological responses to this mucosal pathogen, identification of optimal vaccine antigens and selection of suitable adjuvant delivery systems that engender protective immunity. Fortunately, Chlamydia vaccinology is facilitated by genomic knowledge and by murine models that reproduce many of the features of human C. trachomatis infection. This article reviews recent progress in these areas with a focus on subunit vaccine development.
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