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Mass Measurement and Top-Down HPLC/MS Analysis of Intact Monoclonal Antibodies on a Hybrid Linear Quadrupole Ion Trap-Orbitrap Mass Spectrometer
Pavel V. Bondarenko et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2009)
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
Aran F. Labrijn et al.
NATURE BIOTECHNOLOGY (2009)
Critical comparison of MS and immunoassays for the bioanalysis of therapeutic antibodies
Eric Ezan et al.
BIOANALYSIS (2009)
Absolute quantification of monoclonal antibodies in biofluids by liquid chromatography-tandem mass spectrometry
Charlotte Hagman et al.
ANALYTICAL CHEMISTRY (2008)
Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry
Olivier Heudi et al.
ANALYTICAL CHEMISTRY (2008)
Selection of reaction additives used in the preparation of monomeric antibody-calicheamicin conjugates
Irwin Hollander et al.
BIOCONJUGATE CHEMISTRY (2008)
Contribution of linker stability to the activities of anticancer immunoconjugates
Stephen C. Alley et al.
BIOCONJUGATE CHEMISTRY (2008)
Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
Gail D. Lewis Phillips et al.
CANCER RESEARCH (2008)
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Roxana M. Ionescu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath R. Junutula et al.
NATURE BIOTECHNOLOGY (2008)
The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations
Himanshu S. Gadgil et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
Analysis of post-translational modifications in recombinant monoclonal antibody IgG1 by reversed-phase liquid chromatography/mass spectrometry
Boxu Yan et al.
JOURNAL OF CHROMATOGRAPHY A (2007)
Characterization of variable regions of monoclonal antibodies by top-down mass spectrometry
Zhongqi Zhang et al.
ANALYTICAL CHEMISTRY (2007)
Immuno-mass spectrometry assay of EPI-HNE4, a recombinant protein inhibitor of human elastase
Mathieu Dubois et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2007)
Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis
Himanshu S. Gadgil et al.
ANALYTICAL BIOCHEMISTRY (2006)
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment
Charlotte F. McDonagh et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2006)
Effects of protein aggregates: An immunologic perspective
Amy S. Rosenberg
AAPS JOURNAL (2006)
Evidence for macromolecular protein rings in the absence of bulk water
BT Ruotolo et al.
SCIENCE (2005)
Acidified acetonitrile and methanol extractions for quantitative analysis of acylcarnitines in plasma by stable isotope dilution tandem mass spectrometry
AP Liu et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)
Structural characterization of the maytansinoid -: monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
LT Wang et al.
PROTEIN SCIENCE (2005)
Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides
MMC Sun et al.
BIOCONJUGATE CHEMISTRY (2005)
Structural characterization of a recombinant monoclonal antibody by electrospray time-of-flight mass spectrometry
LT Wang et al.
PHARMACEUTICAL RESEARCH (2005)
Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NSO cells
A Beck et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)
A reversed-phase high-performance liquid chromatography method for analysis of monoclonal antibody-maytansinoid immunoconjugates
MS Fleming et al.
ANALYTICAL BIOCHEMISTRY (2005)
Mass spectral analyses of labile DOTA-NHS and heterogeneity determination of DOTA or DM1 conjugated anti-PSMA antibody for prostate cancer therapy
SX Lu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry
AC Lazar et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2005)
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
KJ Hamblett et al.
CLINICAL CANCER RESEARCH (2004)
Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: Inhibition of aggregation by methoxytriethyleneglycol chains
HD King et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
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