期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 202, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111690
关键词
Hydrothermal synthesis; Graphene; Chitosan; Magnetite; Nanocomposites; Antibacterial activity
资金
- ANID-FONDECYT (Chile) [3180128]
- ANID-FONDEQUIP Grant [EQM130149]
- Millennium Science Initiative of ANID [NCN17_092]
The study investigated chitosan-containing nanocomposites as new antibacterial agents, including magnetite nanoparticles and graphene/CS/Fe3O4 NCs. The Gr/CS/Fe3O4 NCs showed significantly higher antibacterial activity against P. aeruginosa and K. pneumoniae compared to Fe3O4 NPs and CS/Fe3O4 NCs. The synergistic antibacterial activity and easy synthesis of Gr/CS/Fe3O4 NCs suggest their potential for various biomedical applications.
In the present study, chitosan-containing nanocomposites were investigated as new antibacterial agents. Magnetite (Fe3O4) nanoparticles (NPs) as well as chitosan (CS)/Fe3O4 nanocomposites (NCs) and graphene(Gr)/ CS/Fe3O4 NCs were synthesized by simple hydrothermal method. Their composition, structure and morphology were studied, followed by the evaluation of their antibacterial activity against ESBL-producing and gramnegative P. aeruginosa and K. pneumoniae bacterial strains. The Gr/CS/Fe3O4 NCs showed significantly higher antibacterial activity compared to Fe3O4 NPs and CS/Fe3O4 NCs (105 and 69 % higher against P. aeruginosa as well as 91 and 77 % higher against K. pneumoniae, respectively). The minimum inhibitory concentration (MIC) of Gr/CS/Fe3O4 NCs against P. aeruginosa and K. pneumoniae were 60 and 70 mu g/mL, respectively. The synergistic antibacterial activity and facile synthesis of Gr/CS/Fe3O4 NCs suggests their applicability as novel highly efficient antibacterial agents with potential for a wide range of biomedical applications, where antibacterial properties are needed.
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