期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 16, 期 6, 页码 635-639出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737175.2016.1175939
关键词
Interventional MRI; real time; catheter placement; convection enhanced delivery; drug delivery
资金
- Michael J. Fox Foundation
- Voyager Therapeutics, Inc.
- MRI Interventions, Inc.
Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.
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