Synthesis of nanohydroxyapatite/collagen-loaded fucoidan-based composite hydrogel for drug delivery to gastrointestinal cancer cells

The present study aims to evaluate the synthesis of nanohydroxyapatite/collagen-loaded fucoidan-based composite hydrogel and characterized its physico-chemical properties for targeted drug delivery to gastrointestinal cancer cells. The nanomaterial is fabricated and characterized as small spherical nanosheets with a high thermal stability by using Fourier transform infrared (FTIR) analysis, X-ray diffraction (XRD), Thermogravimetric analysis (TGA), UV-vis spectrophotometry (UV-vis), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). in vitro cytotoxicity, BrdU cell proliferation, and scratch assays demonstrate that the nanohydroxyapatite/collagen-loaded fucoidan-based nanomaterial exhibits non-toxicity and increases cell proliferation and migration. in vitro free radical scavenging assays confirm that the fabricated nanomaterial inhibits reactive oxygen species and generates singlet oxygen radicals in the gastrointestinal cancer cells by. The current findings suggest that the proposed nanomaterial can be a potential carrier for the targeted drug delivery to the gastrointestinal cancer cells.

Automated summary

The synthesized nanohydroxyapatite/collagen-loaded fucoidan-based nanomaterial is non-toxic, promotes cell proliferation and migration, and inhibits reactive oxygen species in gastrointestinal cancer cells. These findings suggest its potential as a carrier for targeted drug delivery.