期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 204, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111825
关键词
Polycaprolactone; ZnO; Bone-tendon healing; Antibacterial
资金
- Natural Science Foundation of Hunan Province, China [2018JJ3844, 2019JJ40499]
- Scientific Research Project of Health and Family Planning Commission of Hunan Province, China [B2019188]
- Science and technology Innovation Leading Project for High-tech Industry of Hunan Province [2020SK2008]
- Major science and technology projects of Changsha City [kh2003016]
- Young Science Foundation of Xiangya Hospital Central South University [2017Q07]
- Postdoctoral Research Program of Xiangya Hospital Central South University [223551]
- National key research and development project [2016YFC1100605, 2018YFB1105504]
- Natural Science Foundation of China [82002277, 81672656]
- Clinical research fund of National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) [2020LNJJ15]
- Natural Science Foundation of Changsha City [kq2007069]
- China Postdoctoral Science Foundation [2020M670105ZX]
The PCL-5%HA-1%ZnO films show excellent cell compatibility and promote bone, cartilage, fibrocartilage, and tendon healing, as well as displaying antibacterial characteristics, indicating great potential for application in BTI repair.
The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material characteristics were tested. After culturing MC3T-E1 cells, ATDC5 cells, mouse primary fibrochondrocytes, and mouse primary tenocytes on films, PCL-5%HA-1%ZnO films (HA and ZnO weight ratios of 5% and 1%, respectively) displayed superior cell compatibility and cell adhesion. PCL-5%HA-1%ZnO films also promoted osteogenesis, chondrogenesis, fibrocartilage formation, and tendon healing. The antibacterial characteristics of PCL-5%HA-1%ZnO films were also identified in this study. The PCL-5%HA-1%ZnO films have great application potential in the field of BTI repair.
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