期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 624, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.126805
关键词
Al-MCM-41; Chitosan; Composite; Levofloxacin; Loading; Release
资金
- Deanship of Scientific Research at Princess Nourah bint Abdulrahman University [RG-1441-0002]
The study demonstrated the synthesis of Al-MCM-41 from natural microcline as a novel drug carrier with enhanced technical properties integrated with chitosan for the delivery of levofloxacin. The hybrid structure showed significant loading capacity, controlled release rate, and biocompatibility, making it a promising delivery system for the drug.
The presented study focused on the production of a promising delivery system for levofloxacin drug (LVX) of significant loading capacity, controlled release rate, and low preparation cost. Synthesis of Al-MCM-41 from natural microcline as innovative mesoporous structure and integrated it in nanocomposite with chitosan (CS/Al-MCM) resulted in a hybrid structure of enhanced technical properties as drug carrier of significant biocompatibility. Natural microcline was used in the synthesis of Al-MCM-41 by hydrothermal treatment in the existence of an organic template for 24 h at 110 degrees C. The product was integrated with chitosan into a composite (CS/Al-MCM) which was applied as a carrier for LVX with a loading capacity of 480.6 mg/g which is higher than chitosan (188.8 mg/g) and Al-MCM-41 (340 mg/g). The loading reactions of CS/Al-MCM followed the Pseudo-Second-order kinetic behavior and Langmuir isotherm properties. The theoretical models suggested a homogenous and monolayer loading process that involved chemical and physical reactions of exothermic and spontaneous properties. The CS/Al-MCM showed a significant release profile for 180 h with a maximum release percentage of 96.2%. The LVX release properties followed the Korsmeyer-Peppas behavior with a diffusion exponent related to both diffusion and erosion release mechanisms. The cytotoxicity properties of CS/Al-MCM and LVX loaded CS/ Al-MCM declared their safety and biocompatible effect on human bronchial epithelia.
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