期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 16, 期 4, 页码 449-459出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.2016.1142877
关键词
point-of-care; diagnostics; resource-limited settings; infectious diseases; Technical challenges
类别
资金
- NIH [R01 DE02497101, U54EB015408, R01 GM108584]
- Fundamental Research Funds for the Central Universities from China [2015QNA7026]
The striking prevalence of HIV, TB and malaria, as well as outbreaks of emerging infectious diseases, such as influenza A (H7N9), Ebola and MERS, poses great challenges for patient care in resource-limited settings (RLS). However, advanced diagnostic technologies cannot be implemented in RLS largely due to economic constraints. Simple and inexpensive point-of-care (POC) diagnostics, which rely less on environmental context and operator training, have thus been extensively studied to achieve early diagnosis and treatment monitoring in non-laboratory settings. Despite great input from material science, biomedical engineering and nanotechnology for developing POC diagnostics, significant technical challenges are yet to be overcome. Summarized here are the technical challenges associated with POC diagnostics from a RLS perspective and the latest advances in addressing these challenges are reviewed.
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