期刊
CLINICAL SCIENCE
卷 135, 期 14, 页码 1649-1668出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20200300
关键词
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资金
- National Health and Medical Research Council (NHMRC) of Australia CJ Martin Fellowship [GNT1112125]
In the past two decades, novel anti-cancer therapies such as VEGFIs and ICIs have significantly improved treatment outcomes for a wide range of malignancies, but they are also associated with specific cardiovascular toxicities. Combining these two therapies may become an important direction for future treatment strategies, but it also poses an increased risk of cardiovascular toxicity, requiring close monitoring and evaluation by specialized teams.
In the past two decades, treatment outcomes for a wide range of malignancies have improved remarkably due to the development of novel anti-cancer therapies, including vascular endothelial growth factor inhibitors (VEGFIs) and immune checkpoint inhibitors (ICIs). Despite their unprecedented anti-tumour effects, it is becoming increasingly clear that both types of agents are associated with specific cardiovascular toxicity, including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently, VEGFI and ICI combination therapy will most likely become an important therapeutic strategy for various malignancies. However, this combinatory approach is expected to be accompanied by a substantial increase in cardiovascular risk, as both types of agents could act synergistically to induce cardiovascular sequelae. Therefore, a comprehensive baseline assessment and adequate monitoring by specialised cardio-oncology teams is essential in case these agents are used in combination, particularly in high-risk patients. This review summarises the mechanisms of action and treatment indications for currently registered VEGFIs and ICIs, and discusses their main vascular and cardiac toxicity. Subsequently, we provide the biological rationales for the observed promising synergistic anti-tumour effects of combined VEGFI/ICI administration. Lastly, we speculate on the increased risk for cardiovascular toxicity in case these agents are used in combination and its implications and future directions for the clinical situation.
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