4.5 Article

Patients with acute myocarditis and preserved systolic left ventricular function: comparison of global and regional longitudinal strain imaging by echocardiography with quantification of late gadolinium enhancement by CMR

期刊

CLINICAL RESEARCH IN CARDIOLOGY
卷 110, 期 11, 页码 1792-1800

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00392-021-01885-0

关键词

Myocarditis; CMR; Speckle tracking; Regional longitudinal strain

资金

  1. Projekt DEAL

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In patients with acute myocarditis and preserved LVEF, a significant reduction of GLS was detected compared to healthy subjects, particularly in the lateral, inferolateral, and inferior segments. Additionally, RLS values provided important information about the localization and extent of myocardial injury, especially in segments without LGE.
Background Conventional transthoracic echocardiography (TTE) does often not accurately reveal pathologies in patients with acute myocarditis and preserved left ventricular ejection fraction (LVEEF). Therefore, we investigated the diagnostic value of two-dimensional (2D) speckle tracking echocardiography compared to late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) imaging in patients with acute myocarditis and normal global LVEF. Methods and results 31 patients (group 1) with the diagnosis of acute myocarditis confirmed by CMR according to the Lake Louise criteria and 20 healthy controls (group 2) were analyzed including global longitudinal strain (GLS) and regional longitudinal strain (RLS) derived by the bull's eye plot. Although preserved LVEF was present in both groups, GLS was significantly lower in patients with acute myocarditis (group 1: GLS - 19.1 +/- 1.8% vs. group 2: GLS - 22.1 +/- 1.7%, p < 0.001). Compared to controls, lower RLS values were detected predominantly in the lateral, inferolateral, and inferior segments in patients with acute myocarditis. Additionally RLS values were significantly lower in segments without LGE. Conclusion In patients with acute myocarditis and preserved LVEF, a significant reduction of GLS compared to healthy subjects was detected. Further RLS adds important information to the localization and extent of myocardial injury. [GRAPHICS] .

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