相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation
Ta-Ming Liu et al.
BLOOD (2015)
Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib
Clare Sun et al.
BLOOD (2015)
CXCL13 antibody for the treatment of autoimmune disorders
Ekaterina Klimatcheva et al.
BMC IMMUNOLOGY (2015)
Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis
Anna-Karin E. Palm et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2015)
Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice
James B. Case et al.
JOURNAL OF IMMUNOLOGY (2015)
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
Christopher M. Tipton et al.
NATURE IMMUNOLOGY (2015)
X-linked agammaglobulinemia in two siblings with a novel mutation in the BTK gene who presented with polyarticular juvenile idiopathic arthritis
T. Patiroglu et al.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2015)
Ibrutinib for the treatment of Waldenstrom macroglobulinemia
Rajshekhar Chakraborty et al.
EXPERT REVIEW OF HEMATOLOGY (2015)
Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants
Linda M. Hartkamp et al.
ANNALS OF THE RHEUMATIC DISEASES (2015)
Structure-Based Drug Design of RN486, a Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis
Yan Lou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Functional characterization of BTKC481S mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors
S. Cheng et al.
LEUKEMIA (2015)
Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106
Rehan Zafar Paracha et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY (2014)
Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells
Jingming Wang et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2014)
Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation
Vassilios Lougaris et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Autoimmunity and Inflammation in X-linked Agammaglobulinemia
Vivian P. Hernandez-Trujillo et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2014)
Bruton's Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells
Rachel H. Bonami et al.
JOURNAL OF IMMUNOLOGY (2014)
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial
Susan O'Brien et al.
LANCET ONCOLOGY (2014)
Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
Jennifer A. Woyach et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Richard R. Furman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Bruton's Tyrosine Kinase (BTK) Inhibitors in Clinical Trials
Jan A. Burger
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2014)
Pre-B Cell Receptor Signaling Induces Immunoglobulin k Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions
Ralph Stadhouders et al.
PLOS BIOLOGY (2014)
Suppression of Glomerulonephritis in Lupus-Prone NZB x NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase
Paola Mina-Osorio et al.
ARTHRITIS AND RHEUMATISM (2013)
Expansion of Autoreactive Unresponsive CD21/low B Cells in Sjogren's SyndromeAssociated Lymphoproliferation
D. Saadoun et al.
ARTHRITIS AND RHEUMATISM (2013)
Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients
Betty Y. Chang et al.
BLOOD (2013)
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
Jason A. Dubovsky et al.
BLOOD (2013)
Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease
Donna K. Finch et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2013)
Specific peripheral B cell tolerance defects in patients with multiple sclerosis
Tuure Kinnunen et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
Ranjana H. Advani et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Ibrutinib and novel BTK inhibitors in clinical development
Akintunde Akinleye et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2013)
Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis
Andrew L. Rankin et al.
JOURNAL OF IMMUNOLOGY (2013)
Tolerant Anti-Insulin B Cells Are Effective APCs
Peggy L. Kendall et al.
JOURNAL OF IMMUNOLOGY (2013)
Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
James E. Neffendorf et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
John C. Byrd et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Novel small molecule therapeutics in rheumatoid arthritis
Victoria Kelly et al.
RHEUMATOLOGY (2013)
Inhibitors of BTK and ITK: State of the New Drugs for Cancer, Autoimmunity and Inflammatory Diseases
L. Vargas et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2013)
IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
Ioannis Kalampokis et al.
ARTHRITIS RESEARCH & THERAPY (2013)
Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans
Erica K. Evans et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
Laurens P. Kil et al.
BLOOD (2012)
Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders
Tadeusz Robak et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)
Increased Pro-inflammatory Cytokine Production After Lipopolysaccharide Stimulation in Patients with X-linked Agammaglobulinemia
Maria Edith Gonzalez-Serrano et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2012)
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus
Jack Hutcheson et al.
ARTHRITIS RESEARCH & THERAPY (2012)
RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
Daigen Xu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Anergic Responses Characterize a Large Fraction of Human Autoreactive Naive B Cells Expressing Low Levels of Surface IgM
Tam D. Quach et al.
JOURNAL OF IMMUNOLOGY (2011)
Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy
Lichuan Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis
Julie A. Di Paolo et al.
NATURE CHEMICAL BIOLOGY (2011)
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
Xingguang Liu et al.
NATURE IMMUNOLOGY (2011)
More than just B-cell inhibition
Eric M. Ruderman et al.
ARTHRITIS RESEARCH & THERAPY (2011)
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells
Betty Y. Chang et al.
ARTHRITIS RESEARCH & THERAPY (2011)
The Role of Bruton's Tyrosine Kinase in B-Cell Development and Function in Mice and Mana
WASIF N. KHAN et al.
Annals of the New York Academy of Sciences (2010)
Genes on the X chromosome affect development of collagen-induced arthritis in mice
L. JANSSON et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)
Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells
Rogier Kersseboom et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
CXCL13 Blockade Disrupts B Lymphocyte Organization in Tertiary Lymphoid Structures without Altering B Cell Receptor Bias or Preventing Diabetes in Nonobese Diabetic Mice
Rachel A. Henry et al.
JOURNAL OF IMMUNOLOGY (2010)
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Lee A. Honigberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Reduced Diabetes in btk-Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-Insulin IgH Chain Transgene
Peggy L. Kendall et al.
JOURNAL OF IMMUNOLOGY (2009)
Dual functions of Bruton's tyrosine kinase and tec kinase during Fcγ receptor-induced signaling and phagocytosis
Jenny Jongstra-Bilen et al.
JOURNAL OF IMMUNOLOGY (2008)
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells
Kristina E. Halcomb et al.
MOLECULAR IMMUNOLOGY (2008)
Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes
Peggy L. Kendall et al.
JOURNAL OF IMMUNOLOGY (2007)
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
Zhengying Pan et al.
CHEMMEDCHEM (2007)
Bruton's tyrosine kinase and phospholipase C gamma 2 mediate chemokine-controlled B cell migration and homing
David J. J. de Gorter et al.
IMMUNITY (2007)
BDTKbase:: The mutation database for X-linked agammaglobullinemia
Jouni Valiaho et al.
HUMAN MUTATION (2006)
Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase
Kuo-Chun Huang et al.
JOURNAL OF BIOMOLECULAR NMR (2006)
X-linked Agammaglobulinemia - Report on a United States registry of 201 patients
Jerry A. Winkelstein et al.
MEDICINE (2006)
The health status and quality of life of adults with X-linked agammaglobulinemia
V Howard et al.
CLINICAL IMMUNOLOGY (2006)
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3
Y Kawakami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
S Middendorp et al.
BLOOD (2005)
A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation
SL Guo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Peritoneal B cells govern the outcome of diabetes in non-obese diabetic mice
PL Kendall et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2004)
Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model
M Cetkovic-Cvrlje et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses
A Mangla et al.
BLOOD (2004)
B cell antigen receptor signaling 101
JM Dal Porto et al.
MOLECULAR IMMUNOLOGY (2004)
Bruton's tyrosine kinase is essential for human B cell tolerance
YS Ng et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
B Cell receptor directs the activation of NFAT and NF-κB via distinct molecular mechanisms
P Antony et al.
EXPERIMENTAL CELL RESEARCH (2003)
Predominant autoantibody production by early human B cell precursors
H Wardemann et al.
SCIENCE (2003)
Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice
LR Whyburn et al.
JOURNAL OF IMMUNOLOGY (2003)
Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity
S Middendorp et al.
JOURNAL OF IMMUNOLOGY (2003)
BTK regulates Ptdlns-4,5-P-2 synthesis: Importance for calcium signaling and PI3K activity
K Saito et al.
IMMUNITY (2003)
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils - Implication of phosphatidylinositol 3-kinases
G Lachance et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice
S Middendorp et al.
JOURNAL OF IMMUNOLOGY (2002)
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia
C Mao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Brief report - Development of type 1 diabetes despite severe hereditary B-cell deficiency
S Martin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
BLNK mediates Syk-dependent Btk activation
Y Baba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes
JB Petro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase
WN Khan
IMMUNOLOGIC RESEARCH (2001)
Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement
JB Petro et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
分享论文
