期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 13, 期 2, 页码 101-115出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2016.1224664
关键词
Common variable immunodeficiency; autoimmunity; autoantibody; management; primary antibody deficiency
类别
Introduction: Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency.Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infiltrates, malignancy, inflammatory and autoimmune conditions are also prevalent. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and creates difficulties in the management of autoimmune complications affecting these patients.Expert commentary: The management of autoimmunity in patients with CVID requires special considerations because dysregulation and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment.
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