期刊
CLINICAL NEUROLOGY AND NEUROSURGERY
卷 205, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.clineuro.2021.106625
关键词
Progressive Multifocal Leukoencephalopathy; L-selectin; Immunosenescence; Immunocompetent; Ageing
This article presents a rare case of PML in an elderly patient without known factors of immunosuppression or immunomodulation. The authors evaluated T-cell L-selectin expression levels and serum anti-JCV antibody index to explore mechanistic insights into pathways that may contribute to PML development in this rare clinical setting.
Progressive multifocal leukoencephalopathy (PML) is attributed to reactivation of the John Cunningham virus (JCV), in the central nervous system as a result of immunosuppression. Low L-selectin (CD62L) expression on cryopreserved T-cells has been advocated as a biomarker for natalizumab related PML in patients with RelapsingRemitting Multiple Sclerosis. A rare case of PML in an elderly patient without known factors of immunosuppression or immunomodulation is hereby presented. T-cell L-selectin expression levels and serum anti-JCV antibody index were evaluated in order to explore mechanistic insight to the pathways that presumably contribute towards PML development in this rare clinical setting.
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