期刊
CLINICAL LUNG CANCER
卷 23, 期 1, 页码 E1-E4出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.cllc.2021.05.011
关键词
Multiple primary tumors; Lung adenocarcinoma; KRAS; Germline mutations; ChEK2 mutations
类别
Patients with lung cancer are at increased risk for multiple primary lung cancers, which require thorough diagnostics and individualized treatment options.
Patients with one form of cancer are at increased risk for another, and this is true for lung cancer, where synchronous primary lung cancers are an increasing multifaceted challenge. 1,2 Here, we present the case of a middle age woman who was found to have bilateral lung masses. Biopsy and subsequent testing revealed unique synchronous lung adenocarcinomas, each with unique genetic signatures. Despite having two unique tumors, she was found to have CHEK2 mutations in both tumors and in germline testing. Because of this extensive testing that showed unique tumors, she was ultimately diagnosed with stage IIIb and IA2 lung cancers, and this changed her treatment options. Consideration of unique primary tumors leads to thorough diagnostics, which changed this patient's diagnosis, prognosis, and treatment. We hope this case raises awareness for multiple primary tumors, as well as CHEK2 as an important oncogene.
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