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KJ Hamblett et al.
CLINICAL CANCER RESEARCH (2004)
Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types - An immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura
M Miettinen et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2003)
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas
FR Hirsch et al.
BRITISH JOURNAL OF CANCER (2002)
Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-Doxorubicin in patients with Lewis Y-expressing epithelial tumors
MN Saleh et al.
JOURNAL OF CLINICAL ONCOLOGY (2000)