Post-Transplant Cardiovascular Disease

Cardiovascular disease remains a leading cause of death and morbidity in kidney transplant recipients and a common reason for post-transplant hospitalization. Several traditional and nontraditional cardiovascular risk factors exist, and many of them present pretransplant and worsened, in part, due to the addition of immunosuppression post-transplant. We discuss optimal strategies for identification and treatment of these risk factors, including the emerging role of sodium-glucose cotransporter 2 inhibitors in post-transplant diabetes and cardiovascular disease. We present common types of cardiovascular disease observed after kidney transplant, including coronary artery disease, heart failure, pulmonary hypertension, arrhythmia, and valvular disease. We also discuss screening, treatment, and prevention of post-transplant cardiac disease. We highlight areas of future research, including the need for goals and best medications for risk factors, the role of biomarkers, and the role of screening and intervention.

Automated summary

Cardiovascular disease remains a major cause of death and hospitalization in kidney transplant recipients. Identifying and treating cardiovascular risk factors, as well as exploring emerging therapies like sodium-glucose cotransporter 2 inhibitors, are crucial in post-transplant care. Future research areas include setting goals for risk factor management, utilizing biomarkers, and improving screening and intervention strategies.