期刊
CLINICAL INFECTIOUS DISEASES
卷 74, 期 4, 页码 715-718出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab465
关键词
COVID-19; mRNA vaccine; SARS-CoV-2 antigens; immune responses; spike
资金
- Chleck Foundation
- Bill and Melinda Gates Foundation [INV-017380]
- National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID)
- Welcome Trust
- International AIDS Vaccine Initiative (IAVI)
- NIH [T32HL007627]
- Bill and Melinda Gates Foundation [INV-017380] Funding Source: Bill and Melinda Gates Foundation
The study found that most participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after receiving the mRNA-1273 vaccine, and the clearance of detectable SARS-CoV-2 protein correlated with the production of immunoglobulin G (IgG) and immunoglobulin A (IgA).
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).
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