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Article
Immunology
Barnaby E. Young et al.
Summary: The study found that virus viability correlated with lower PCR Ct values in early illness, and a stronger antibody response was associated with disease severity. Overactive proinflammatory immune signatures provide potential targets for host-directed immunotherapy.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Rachael Pung et al.
Summary: Comprehensive surveillance and early case detection in Singapore have effectively contained the spread of COVID-19. The mean serial interval was estimated to be 4.6 days with the majority of time having a reproduction number below 1. This suggests that robust surveillance and containment measures were successful in keeping the outbreak under control.
Article
Biochemistry & Molecular Biology
Erik Volz et al.
Summary: The study suggests a positive selection for the SARS-CoV-2 spike protein variant D614G in the UK, but no evidence of differences in COVID-19 mortality or clinical severity in patients infected with this variant. 614G is associated with higher viral load and younger age of patients compared to 614D.
Article
Infectious Diseases
Paolo Calistri et al.
Summary: A targeted surveillance in the Abruzzo region of Italy detected 313 persons affected by lineage B.1.1.7, with statistically significant differences in viral load and persistence compared to other lineages. In individuals infected with B.1.1.7 lineage, lower values of C-T associated with the detection of the N protein encoding gene and longer persistence of SARS-CoV-2 RNA in nasopharyngeal swabs were observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Michael Kidd et al.
Summary: Analysis of recent test data shows that samples containing the SARS-CoV-2 variant B1.1.7 with mutation Delta 69/70 exhibit S gene target failure (SGTF) in ThermoFisher TaqPath RT-qPCR. Samples with SGTF profile are more likely to have higher viral loads, indicating higher infectivity and rapid spread of this variant.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Houriiyah Tegally et al.
Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.
Article
Multidisciplinary Sciences
Pengfei Wang et al.
Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Medicine, General & Internal
Robert Challen et al.
Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Infectious Diseases
Daniel J. Grint et al.
Summary: The SARS-CoV-2 B.1.1.7 VOC is spreading across Europe and poses a higher risk of death compared to non-VOC cases, with increased mortality in older individuals and those with comorbidities. This variant has the potential to spread faster and cause higher mortality than previous strains.
Editorial Material
Infectious Diseases
Sean Wei Xiang Ong et al.
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Dan Frampton et al.
Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.
LANCET INFECTIOUS DISEASES
(2021)
News Item
Multidisciplinary Sciences
Gayathri Vaidyanathan
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.
Article
Multidisciplinary Sciences
Erik Volz et al.
Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.
Letter
Medicine, General & Internal
Laith J. Abu-Raddad et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
V. Shinde et al.
Summary: The NVX-CoV2373 vaccine showed efficacy in preventing Covid-19, with higher vaccine efficacy observed among HIV-negative participants. Most infections were caused by the B.1.351 variant.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nuno R. Faria et al.
Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.
Article
Medicine, General & Internal
Jamie Lopez Bernal et al.
Summary: This study estimated the real-world effectiveness of Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed COVID-19 symptoms, hospital admissions, and deaths. The vaccines showed significant reduction in symptomatic COVID-19 among older adults and further protection against severe disease. Both vaccines demonstrated similar effects and protection was maintained for over 6 weeks.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Letter
Medicine, General & Internal
Aziz Sheikh et al.
Review
Microbiology
William T. Harvey et al.
Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Immunology
Jared Bullard et al.
CLINICAL INFECTIOUS DISEASES
(2020)
Editorial Material
Public, Environmental & Occupational Health
Vernon J. Lee et al.
JOURNAL OF TRAVEL MEDICINE
(2020)
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Jesse Fajnzylber et al.
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Pei Hua Lee et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)
